By Tomoyoshi Nozaki, Alok Bhattacharya
This ebook records and offers new advancements within the learn of amebiasis, one of many ignored tropical ailments. approximately 50 million humans world wide are contaminated with the pathogen Entamoeba histolytica, inflicting large-scale morbidity and mortality fairly in constructing international locations. This publication can help clinicians for larger analysis and administration of the disorder, researchers for beginning learn initiatives on a number of the poorly understood facets of the illness and the pathogen, and scholars for updating their wisdom. the themes coated diversity from genomics and molecular and telephone biology to drug resistance and new drug improvement, highlighting significant advances in recent times in our realizing because of swift growth in genomic and different biomedical applied sciences, equivalent to visualization of molecular techniques. many of the chapters supply contemporary info in keeping with newest guides. a number of chapters describe the various severe methodological matters that would be worthwhile for college kids and researchers attracted to moving into the sphere. The contributing authors contain just about all the lively researchers and clinicians from worldwide. This ebook may be an invaluable fundamental fabric and a helpful resource of data for someone drawn to figuring out amebiasis, its prognosis, and remedy. it is going to even be worthwhile to people who have an interest in studying concerning the biology of early branching eukaryotes and protist pathogens.
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Additional info for Amebiasis: Biology and Pathogenesis of Entamoeba
Silberman JD, Clark CG, Diamond LS, Sogin ML (1999) Phylogeny of the genera Entamoeba and Endolimax as deduced from small-subunit ribosomal RNA sequences. Mol Biol Evol 16:1740–1751 29. Clark CG, Kaffashian F, Tawari B, Windsor JJ, Twigg-Flesner A, Davies-Morel MCG, Blessmann J, Ebert F, Pesche B, Le Van A, Jackson CJ, Macfarlane L, Tannich E (2006) New insights into the phylogeny of Entamoeba species provided by analysis of four new smallsubunit rRNA genes. Int J Syst Evol Microbiol 56:2235–2239 30.
Histolytica karyotype, it has been proposed that the genome contains a mixture of linear and circular molecules [49–52]. A circular molecule contains the E. histolytica ribosomal RNA genes, and multiple copies of this molecule exist in the nucleus . In D. discoideum, a chromosomal region containing rRNA genes appears to act as a “master copy” to generate many linear extrachromosomal molecules encoding these genes [43, 54]. No obvious candidate for such a “master copy” of rRNA genes has been found in the E.
D. Weedall although the sizes of these putative chromosomes varied between E. histoytica strains, and multiple bands (often four) were frequently present within a single strain, which led the authors to suggest a ploidy of four or more . The natural ploidy of E. histolytica is unknown. It appears to be variable under different growth conditions, with up to tenfold more genome copies per cell under axenic growth conditions than is common when cells are grown in the presence of bacteria .
Amebiasis: Biology and Pathogenesis of Entamoeba by Tomoyoshi Nozaki, Alok Bhattacharya