By T. Scott Stroup, Jeffrey A. Lieberman

ISBN-10: 0521895332

ISBN-13: 9780521895330

Antipsychotic medicines are a key remedy for schizophrenia and revenues of antipsychotic medicinal drugs technique $20 billion in step with 12 months, with fierce advertising and marketing among the makers of the medication. The U.S. nationwide Institute of psychological future health subsidized the scientific Antipsychotic Trials of Intervention Effectiveness (CATIE) venture to supply self sufficient information regarding the comparative effectiveness of medicines. CATIE was once the most important, longest and such a lot accomplished learn of schizophrenia up to now. performed below rigorous double-blind stipulations, Antipsychotic Trials in Schizophrenia offers the definitive archival result of this landmark learn. The middle of the publication comprises chapters excited about particular results that set the CATIE findings in a much wider context. additionally integrated are chapters at the layout, statistical analyses and implications for researchers, clinicians and coverage makers. Psychiatrists, psychiatric researchers, psychological health and wellbeing coverage makers and people operating in pharmaceutical businesses will all locate this to be crucial examining.

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Extra resources for Antipsychotic Trials in Schizophrenia: The CATIE Project

Sample text

Insight in schizophrenia. Its relationship to acute psychopathology. The Journal of Nervous and Mental Disease 1989;177:43–7. 10. Appelbaum PS, Grisso T. MacArthur Competence Assessment Tool for Clinical Research. Sarasota, FL: Professional Resource Press; 2001. 11. Carpenter WT Jr, Gold JM, Lahti AC, et al. Decisional capacity for informed consent in schizophrenia research. Archives of General Psychiatry 2000;57:533–8. 12. Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with schizophrenia.

Chapter 1: Study design and protocol development process 9. McEvoy JP, Apperson LJ, Appelbaum PS, et al. Insight in schizophrenia. Its relationship to acute psychopathology. The Journal of Nervous and Mental Disease 1989;177:43–7. 10. Appelbaum PS, Grisso T. MacArthur Competence Assessment Tool for Clinical Research. Sarasota, FL: Professional Resource Press; 2001. 11. Carpenter WT Jr, Gold JM, Lahti AC, et al. Decisional capacity for informed consent in schizophrenia research. Archives of General Psychiatry 2000;57:533–8.

Medication adherence Medication adherence was measured at each monthly visit using pill counts. In addition, at each visit study personnel synthesized information from the pill count and any other relevant information into a Global Judgment of Medication Adherence. 4). Substance use Substance use was examined in multiple ways. Subjects were asked quarterly about drug and alcohol use. Urine drug screens and radioimmunoassay (RIA) of hair samples were used to detect substances of abuse. The Clinician Alcohol Use Scale and Drug Use Scale were used to rate substance use on a 5-point scale, with anchors ranging from abstinence to dependence requiring institutionalization.

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Antipsychotic Trials in Schizophrenia: The CATIE Project by T. Scott Stroup, Jeffrey A. Lieberman


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