By Chirukandath Gopinath, Visit Amazon's Vasanthi Mowat Page, search results, Learn about Author Central, Vasanthi Mowat,

ISBN-10: 162703997X

ISBN-13: 9781627039970

ISBN-10: 1627039988

ISBN-13: 9781627039987

This atlas comprises greater than seven-hundred illustrations that the authors have accrued through the years in addition to references and data concerning lately constructed drug sessions, together with biologics. it's a helpful bench reference for working towards pathologists and should even be used as a reference textual content by way of different specialists from similar fields. The atlas is organised into assorted chapters in line with systemic pathology. every one bankruptcy has illustrations with legends, and the atlas contains a few infrequent examples of exact lesions came across in the course of toxicity reports over many years.

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Extra info for Atlas of Toxicological Pathology

Sample text

7 FIGURE 2-34. Neuroendocrine cell hyperplasia in the bronchiole of a rat. A polypoid structure composed of round cells with round dark nuclei and scanty cytoplasm protrudes into the bronchiolar lumen. Immunohistochemistry is necessary to differentiate these from similar-appearing lymphoid aggregates. H&E. Terminal Bronchioles/Alveolar Ducts In inhalation studies, induced changes commonly are seen in the terminal bronchioles, where the test material is deposited. The nature of the induced changes depends on several factors including particle size, the nature of the test material, and its pharmacological action.

Metabolism of xenobiotics may occur throughout the respiratory tract, such as in the nose, conducting passages, and airways, producing toxic metabolites. Specific types and concentrations of enzymes differ among regions, the site-specific localisation of enzymes accounting, at least partially, for regional susceptibility or resistance to injury. Enzymes in the respiratory tract include cytochromes P450 (CYPs), monooxygenases, dehydrogenases, prostaglandin C. Gopinath, V. 1007/978-1-62703-998-7_2, © Springer Science+Business Media New York 2014 19 G synthetase, and phase II enzymes such as glucuronyl and glutathione transferases that facilitate excretion.

37. Wronska-Nofer T, Szendzikowski S, Laurman W. The effect of carbon disulphide and atherogenic diet on the development of atherosclerotic changes in rabbits. Atherosclerosis. 1978; 31:33–9. 19. Van Vleet JF, Ferrans VJ. Myocardial diseases of animals. Am J Pathol. 1986;124:98–178. 18 Atlas of Toxicological Pathology 2 The Respiratory System Induced lesions of the respiratory tract are described on an organ-by-organ basis with illustrations. Both nonneoplastic and neoplastic changes of the various regions are covered.

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Atlas of Toxicological Pathology by Chirukandath Gopinath, Visit Amazon's Vasanthi Mowat Page, search results, Learn about Author Central, Vasanthi Mowat,


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